Everything about Macroprolactin totally explained
Macroprolactin is a physiologically inactive form of
prolactin found in a small proportion of people. It is in fact prolactin bound to
IgG.
Macroprolactin is important, as some
laboratory assays will detect it as prolactin, leading to a falsely elevated prolactin result. This can lead to a misdiagnosis of hyperprolactinaemia in some people, especially those with other symptoms, such as
menstrual problems or
infertility.
There are certain chemicals, such as
polyethylene glycol, that can be added to remove macroprolactin from a suspicious sample. The sample can then be re-analysed to see if the prolactin levels are still high.
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